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Pathway Description
Fluticasone propionate Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-06-07
Last Updated: 2023-10-25
Fluticasone propionate is a synthetic glucocorticoid used to treat asthma, as well as inflammatory and pruritic dermatoses. This molecule can also besused as a nasal spray to treat allergic and nonallergic rhinitis. As this molecule is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) of influencing COX-2/prostaglandin G/H synthase 2 suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. This drug also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Fluticasone propionate is administered as an inhaler, a nasal spray or as a topical ointment.
References
Fluticasone propionate Pathway References
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