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Pathway Description
Triamcinolone Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-06-07
Last Updated: 2023-10-25
Triamcinolone is a glucocorticoid used to treat a wide variety of inflammatory conditions. As this drug is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) influencing COX-2/prostaglandin G/H synthase 2 suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Triamcinolone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. This drug is available as tablets, eye drops, creams, intramuscular and intravenous injections, and as a nasal spray.
References
Triamcinolone Pathway References
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