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Serine hydroxymethyltransferase, cytosolic Proton-coupled folate transporter Tetrahydrofolic Acid Transporter Mitochondrial folate transporter/carrier Mitochondrial folate transporter/carrier Dihydrofolate reductase Dihydrofolate reductase Gamma-glutamyl hydrolase Thymidylate synthase Dihydrofolate reductase Levoleucovorin Tetrahydrofolic acid Folic acid Folic acid Tetrahydrofolic acid Levoleucovorin Tetrahydrofolic acid Dihydrofolic acid NADP NADPH NADPH NADP Tetrahydrofolyl-[Glu](n) H2O L-Glutamic acid L-Serine 5,10-Methylene-THF Glycine H2O dUMP dTMP NADPH NADP Purine Metabolism Histidine Metabolism Methionine Metabolism Thymine Synthesis DNA synthesis and replication Glycine and Serine Metabolism Dihydrofolic acid Pyridoxal 5'-phosphate Extracellular Space Cytosol Lysosome Mitochondria Cancer Cell Levoleucovorin acts to inhibit serine hydroxymethyltransferase reducing compounds needed for DNA replication and synthesis. 5,10-Methylene-THF, is an intermediate in many amino acid pathways, such as methionine synthesis. It is also used in thymidine synthesis which is a nucleoside needed for DNA replication Levoleucovorin is administered intravenously and travels directly into the bloodstream
Mitochondria Lysosome SHMT1 SLC46A1 Unknown SLC25A32, MFT, MFTC SLC25A32, MFT, MFTC DHFR DHFR GGH TYMS DHFR Levoleucovorin Tetrahydrofolic acid Folic acid Folic acid Tetrahydrofolic acid Levoleucovorin Tetrahydrofolic acid Dihydrofolic acid NADP NADPH NADPH NADP Tetrahydrofolyl- [Glu](n) Water L-Glutamic acid L-Serine 5,10- Methylene-THF Glycine Water dUMP dTMP NADPH NADP Purine Metabolism Histidine Metabolism Methionine Metabolism Thymine Synthesis DNA synthesis and replication Glycine and Serine Metabolism Dihydrofolic acid
SHMT1 SLC46A1 SLC25A32, MFT, MFTC SLC25A32, MFT, MFTC DHFR DHFR GGH TYMS DHFR Levol THFA Folate Folate THFA Levol THFA FAH2 NADP NADPH NADPH NADP ThGluN H2O Glu Ser 5XM-THF Gly H2O dUMP dTMP NADPH NADP PW000052 PW000043 PW000056 Thy Syn D s a r PW000157 FAH2 Pyr-5'P Extracellular Space Cytosol Lysosome Mitochondria Cancer Cell Levoleucovorin acts to inhibit serine hydroxymethyltransferase reducing compounds needed for DNA replication and synthesis. 5,10-Methylene-THF, is an intermediate in many amino acid pathways, such as methionine synthesis. It is also used in thymidine synthesis which is a nucleoside needed for DNA replication Levoleucovorin is administered intravenously and travels directly into the bloodstream
Mitochondria Lysosome SHMT1 SLC46A1 SLC25A32, MFT, MFTC SLC25A32, MFT, MFTC DHFR DHFR GGH TYMS DHFR Levol THFA Folate Folate THFA Levol THFA FAH2 NADP NADPH NADPH NADP ThGluN H2O Glu Ser 5XM-THF Gly H2O dUMP dTMP NADPH NADP PW000052 PW000043 PW000056 Thy Syn D s a r PW000157 FAH2