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Glutamate receptor 1 Glutamate receptor 2 Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-3 Glutamate [NMDA] receptor subunit epsilon-2 Glutamate [NMDA] receptor subunit epsilon-4 Glutamate [NMDA] receptor subunit 3A Glutamate [NMDA] receptor subunit 3B Sodium channel subunit beta-1 Potassium voltage-gated channel subfamily D member 2 Kv channel- interacting protein 2 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Sodium channel protein type 10 subunit alpha Glutamate Lacosamide K+ K+ Na+ Na+ Ca+ Ca+ Glutamate Na+ Na+ Ca+ Ca+ Ca+ Ca+ Lacosamide Lacosamide Depolarization axon width = 9 Presynaptic Neuron Post-synaptic Neuron Since no action potential arrives to the nerve terminal, calcium entry does not occur and neurotransmitters like glutamate are not released from synaptic vesicles into the synapse. Lacosamide blocks the channel, preventing the entry of sodium into the neuron. Membrane Potential (mV) 0 40 -70 Hyperpolarization Repolarization Peak action potential Resting potential The depolarization phase of the action potential is inhibited, therefore, the action potential cannot be generated. ACTION POTENTIAL Time (ms) Synaptic Vesicle The post synaptic neuron is unable to depolarize due to the inhibition of neurotransmitter release. Lacosamide is administered as an oral tablet
Mitochondria GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B SCN1B KCND2 KCNIP2 CACNA1A CACNB1 CACNA2D2 CACNA1H CACNA1G SCN10A Glutamate Lacosamide Potassium Potassium Sodium Sodium Calcium Calcium Glutamate Sodium Sodium Calcium Calcium Calcium Calcium Lacosamide Lacosamide
GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B SCN1B KCND2 KCNIP2 CACNA1A CACNB1 CACNA2D2 CACNA1H CACNA1G SCN10A Gluta Lacos K+ K+ Na+ Na+ Ca+ Ca+ Gluta Na+ Na+ Ca+ Ca+ Ca+ Ca+ Lacos Lacos Depolarization axon width = 9 Presynaptic Neuron Post-synaptic Neuron Since no action potential arrives to the nerve terminal, calcium entry does not occur and neurotransmitters like glutamate are not released from synaptic vesicles into the synapse. Lacosamide blocks the channel, preventing the entry of sodium into the neuron. Membrane Potential (mV) 0 40 -70 Hyperpolarization Repolarization Peak action potential Resting potential The depolarization phase of the action potential is inhibited, therefore, the action potential cannot be generated. ACTION POTENTIAL Time (ms) Synaptic Vesicle The post synaptic neuron is unable to depolarize due to the inhibition of neurotransmitter release. Lacosamide is administered as an oral tablet
Mitochondria GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B SCN1B KCND2 KCNIP2 CACNA1A CACNB1 CACNA2D2 CACNA1H CACNA1G SCN10A Gluta Lacos K+ K+ Na+ Na+ Ca2+ Ca2+ Gluta Na+ Na+ Ca2+ Ca2+ Ca2+ Ca2+ Lacos Lacos