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Voltage- dependent R-type calcium channel subunit alpha-1E Glutamate receptor 1 Glutamate receptor 2 Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-3 Glutamate [NMDA] receptor subunit epsilon-2 Glutamate [NMDA] receptor subunit epsilon-4 Glutamate [NMDA] receptor subunit 3A Glutamate [NMDA] receptor subunit 3B Sodium channel subunit beta-1 Potassium voltage-gated channel subfamily D member 2 Kv channel- interacting protein 2 Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Sodium channel Glutamate Rufinamide K+ K+ Glutamate Na+ Na+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ Ca+ Ca+ Rufinamide Rufinamide Depolarization axon width = 9 Presynaptic Neuron Post-synaptic Neuron Since no action potential arrives to the nerve terminal, calcium entry does not occur and neurotransmitters like glutamate are not released from synaptic vesicles into the synapse. Rufinamide blocks sodium channels, preventing the entry of sodium into the neuron. Membrane Potential (mV) 0 40 -70 Hyperpolarization Repolarization Peak action potential Resting potential The depolarization phase of the action potential is inhibited, therefore, the action potential cannot be geenrated. ACTION POTENTIAL Time (ms) The post synaptic neuron is unable to depolarize due to the inhibition of neurotransmitter release Synaptic Vesicle Rufinamide is administered as an oral tablet
Mitochondria CACNA1E GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B SCN1B KCND2 KCNIP2 CACNA1H CACNA1G SCN10A Glutamate Rufinamide Potassium Potassium Glutamate Sodium Sodium Calcium Calcium Calcium Calcium Sodium Sodium Calcium Calcium Rufinamide Rufinamide
CACNA1E GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B SCN1B KCND2 KCNIP2 CACNA1H CACNA1G SCN10A Gluta Rufin K+ K+ Gluta Na+ Na+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ Ca+ Ca+ Rufin Rufin Depolarization axon width = 9 Presynaptic Neuron Post-synaptic Neuron Since no action potential arrives to the nerve terminal, calcium entry does not occur and neurotransmitters like glutamate are not released from synaptic vesicles into the synapse. Rufinamide blocks sodium channels, preventing the entry of sodium into the neuron. Membrane Potential (mV) 0 40 -70 Hyperpolarization Repolarization Peak action potential Resting potential The depolarization phase of the action potential is inhibited, therefore, the action potential cannot be geenrated. ACTION POTENTIAL Time (ms) The post synaptic neuron is unable to depolarize due to the inhibition of neurotransmitter release Synaptic Vesicle Rufinamide is administered as an oral tablet
Mitochondria CACNA1E GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B SCN1B KCND2 KCNIP2 CACNA1H CACNA1G SCN10A Gluta Rufin K+ K+ Gluta Na+ Na+ Ca2+ Ca2+ Ca2+ Ca2+ Na+ Na+ Ca2+ Ca2+ Rufin Rufin