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Pathway Description
Magnesium Sulfate Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-06-21
Last Updated: 2023-11-27
Magnesium sulfate is a drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. It can be found under the brand names Concept Ob, Suprep Bowel Prep Kit, and Tis-U-sol. A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. Magnesium is the second most plentiful cation of the intracellular fluids. It is essential for the activity of many enzyme systems and plays an important role with regard to neurochemical transmission and muscular excitability. Magnesium sulfate reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholine release at the myoneural junction. Additionally, Magnesium inhibits Ca2+ influx through dihydropyridine-sensitive, voltage-dependent channels. This accounts for much of its relaxant action on vascular smooth muscle. Possible side effects may include skin rash, itching, confusion, and drowsiness.
References
Magnesium Sulfate Pathway References
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