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Pathway Description
Desipramine Action Pathway (New)
Homo sapiens
Drug Action Pathway
Created: 2023-06-21
Last Updated: 2023-11-27
Desipramine, also known as Norpramin, is a dibenzazepine-derivative tricyclic antidepressant (TCA) used in the treatment of depression. In non-depressed individuals, desipramine does not affect mood but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. Secondary amine TCAs, such as desipramine, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs. It can also be used to manage chronic neuropathic pain, as a second-line agent for the management of anxiety disorders, and as a second or third-line agent in ADHD management. This drug is the active metabolite of imipramine, a tertiary amine TCA. It binds to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter of the presynaptic neurons. In consequence, there is a high concentration of those two neurotransmitters in the synapses. This molecule is administered as an oral tablet.
References
Desipramine Pathway (New) References
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