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Pathway Description
Atomoxetine Action Pathway (New)
Homo sapiens
Drug Action Pathway
Created: 2023-06-21
Last Updated: 2023-11-27
Atomoxetine, also known as Strattera, is a selective norepinephrine reuptake inhibitor (SNRI). It is used in the management of attention deficit hyperactivity disorder (ADHD). Although the underlying pathophysiology that causes ADHD remains undefined, evidence suggests that dysregulation in noradrenergic and dopaminergic pathways plays a critical role. Due to atomoxetine's noradrenergic activity, it also has effects on the cardiovascular system such as increased blood pressure and tachycardia. Atomoxetine binds to the sodium-dependent noradrenaline transporter, this prevents the noradrenaline reuptake in the presynaptic neurons. In consequence, there is more norepinephrine available in the synapses and in the brain in general. This will increase the activation of alpha-adrenergic receptors in the postsynaptic neurons. This activation decreases the inattention of ADHD patients. This drug is administered as an oral capsule.
References
Atomoxetine Pathway (New) References
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