Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 2C Alpha-1A adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor Sodium- dependent serotonin transporter Sodium- dependent noradrenaline transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Dopamine beta- hydroxylase Tyrosine 3-monooxygenase Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Norepinephrine Ca+ Serotonin Serotonin Norepinephrine Doxepin Doxepin Ca+ Norepinephrine Ca+ Serotonin Doxepin Doxepin Doxepin Doxepin L-Dopa Dopamine CO2 Ascorbic acid O2 Dehydroascorbic acid H2O L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Pyridoxal 5'-phosphate Pyrroloquinoline quinone Copper Fe2+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Gq signaling cascade Gs signaling cascade Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse Synapse Mood Improvement Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Doxepin inhibits the serotonin reuptake transporter, thereby increasing synaptic serotonin Serotonin activates 5HT2A and 5HT2C receptors, which are responsible for mood improvements Norepinephrine is synthesized and stored in synaptic vesicles at the nerve terminal Doxepin inhibits the norepinephrine reuptake transporter, thereby increasing synaptic norepinephrine levels Mood Improvement Norepinephrine activates post synaptic adrenergic receptors which are responsible for mood improvements Blood-Brain Barrier Diffusion Blood-Brain Barrier Diffusion
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