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Pathway Description
Imipramine Action Pathway (New)
Homo sapiens
Drug Action Pathway
Created: 2023-06-22
Last Updated: 2023-11-27
Imipramine is a dibenzazepine-derivative tricyclic antidepressant. It is indicated for the treatment of depression and to reduce childhood enuresis. This drug can also be used off-label to manage panic disorders with or without agoraphobia, as a second-line agent for ADHD to manage bulimia nervosa, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, for the treatment of acute stress disorder and posttraumatic stress disorder, and for symptomatic treatment of postherpetic neuralgia and painful diabetic neuropathy. Imipramine binds to the sodium-dependent serotonin transporter and to the sodium-dependent norepinephrine transporter reducing the reuptake of norepinephrine and serotonin by presynaptic neurons. Imipramine displays a much higher affinity for the serotonin reuptake transporter. Imipramine produces effects similar to other monoamine-targeting antidepressants, increasing serotonin- and norepinephrine-based neurotransmission. Depression has been linked to a lack of stimulation of the post-synaptic neuron by norepinephrine and serotonin. Slowing the reuptake of these neurotransmitters increases their concentration in the synapses of the brain. Imipramine is converted to desipramine by CYP1A2, CYP3A4, and CYP2C19 in the liver. Desipramine is also an active metabolite. Central nervous system and neuromuscular effects include drowsiness, lethargy, fatigue, agitation, excitement, nightmares, restlessness, insomnia, confusion, disturbed concentration, disorientation, delusions, and hallucinations. This drug is administered as an oral tablet or capsule.
References
Imipramine Pathway (New) References
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