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Pathway Description
Propiverine Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-06-26
Last Updated: 2023-11-27
Propiverine is an antimuscarinic agent used to treat urinary incontinence or increased urinary frequency or urgency. It can be found under the brand name Mictoryl. Propiverine demonstrates both anticholinergic and calcium-modulating properties. The efferent connection of the pelvic nerve is inhibited due to the anticholinergic action exerted by this drug, leading to relaxation of bladder smooth muscle. Propiverine blocks calcium ion influx and modulates the intracellular calcium in urinary bladder smooth muscle cells, resulting in the inhibition of muscle spasm. The bladder contains several muscarinic receptors. Acetylcholine is the main contractile neurotransmitter in the human bladder detrusor muscle, and antimuscarinics such as propiverine exert their effects by competitively inhibiting the binding of acetylcholine at muscarinic receptors on detrusor smooth muscle cells and other structures within the bladder wall. In one study, After oral treatment with propiverine, the bladder showed the highest concentration of M-2, indicating a targeted distribution of this metabolite into the bladder. Therefore, muscarinic receptor-2 may highly contribute to the relatively selective and long-lasting occupation of bladder muscarinic receptors after oral ingestion of propiverine. Possible side effects of using propiverine may include dry mouth, headache, constipation, dizziness.
References
Propiverine Pathway References
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