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Gq protein
signaling
cascade
Phospholipase C
Inositol 1,4,5-
trisphosphate
receptor type 1
Protein kinase
C alpha type
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Myosin light
chain kinase,
smooth muscle
Muscarinic
acetylcholine
receptor M1
Myosin LC-P
Myosin light
chain 3
Calmodulin-1
Myosin light
chain
phosphatase
Calmodulin-1
Inositol 1,4,5-trisphosphate
Oxyphenonium
Ca
+
Ca
+
Ca
+
Oxyphenonium
Phosphatidylinositol
4,5-bisphosphate
Calcium
Ca
+
Diacylglycerol
Muscle
Contraction
Muscle
Relaxation
Magnesium
Calcium
Manganese
Sarcoplasmic Reticulum
Myosin unbinds from actin
causing muscle relaxation
Decreased calcium is unable
to bind readily to
calmodulin so it does not
activate myosin light chain
kinase
Activation of myosin light
chain kinase leading to high
concentration of myosin LC-P
There is an overall decrease
in calcium levels in the
cytosol caused by the
inhibition of the Gq
signaling cascade
Cytosol
Smooth Muscle Myocyte
Oxyphenonium is an
antagonist of the muscarinic
acetylcholine receptor M1,
this blocks acetylcholine
action
Actin
Myosin
Oxyphenonium is administered
as an oral tablet
GNAQ
PLCB1
ITPR1
PRKCA
CACNA1A
CACNB1
CACNA2D2
MYLK
CHRM1
MYL3
MYL3
CALM1
PPP1CB
CALM1
Inositol 1,4,5-
trisphosphate
Oxyphenonium
Calcium
Calcium
Calcium
Oxyphenonium
Phosphatidylinositol
4,5-
bisphosphate
Calcium
Diacylglycerol
Muscle
Contraction
Muscle
Relaxation
GNAQ
PLCB1
ITPR1
PRKCA
CACNA1A
CACNB1
CACNA2D2
MYLK
CHRM1
MYL3
MYL3
CALM1
PPP1CB
CALM1
Inotp
Dcf
Ca
+
Ca
+
Ca
+
Dcf
P45P
Ca2+
Ca
+
Diacylg
Mus Con
Mus Rel
Mg2+
Ca2+
Mn2+
Sarcoplasmic Reticulum
Myosin unbinds from actin
causing muscle relaxation
Decreased calcium is unable
to bind readily to
calmodulin so it does not
activate myosin light chain
kinase
Activation of myosin light
chain kinase leading to high
concentration of myosin LC-P
There is an overall decrease
in calcium levels in the
cytosol caused by the
inhibition of the Gq
signaling cascade
Cytosol
Smooth Muscle Myocyte
Oxyphenonium is an
antagonist of the muscarinic
acetylcholine receptor M1,
this blocks acetylcholine
action
Actin
Myosin
Oxyphenonium is administered
as an oral tablet
GNAQ
PLCB1
ITPR1
PRKCA
CACNA1A
CACNB1
CACNA2D2
MYLK
CHRM1
MYL3
MYL3
CALM1
PPP1CB
CALM1
Inotp
Dcf
Ca2+