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Pathway Description
Podofilox Action Pathway (New)
Homo sapiens
Drug Action Pathway
Created: 2023-06-28
Last Updated: 2023-11-27
Podofilox, also known as Condylox or podophyllotoxin, is an agent used for the treatment of external genital warts (Condyloma acuminatum) and perianal warts. This drug comes from the roots of podophyllum plants. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties. The exact mechanism of action is not clear. It possibly binds and inhibits topoisomerase II during the late S and early G2 stages. This disrupts the reparation of the breaks through which the double-stranded DNA passes. This stops the natural DNA unwinding and, in consequence, the replication of the DNA. The binding and inhibition of the tubulin chain of this drug are also studied. Podofilox is administered as a topical gel/solution only.
References
Podofilox Pathway (New) References
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