Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
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Gq protein signaling cascade Phospholipase C Inositol 1,4,5- trisphosphate receptor type 1 Protein kinase C alpha type Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Myosin light chain kinase, smooth muscle Muscarinic acetylcholine receptor M1 Myosin LC-P Myosin light chain 3 Calmodulin-1 Myosin light chain phosphatase Calmodulin-1 Inositol 1,4,5-trisphosphate Acetylcholine Propantheline Ca+ Ca+ Ca+ Propantheline Phosphatidylinositol 4,5-bisphosphate Calcium Ca+ Diacylglycerol Muscle Contraction Muscle Relaxation Magnesium Calcium Manganese Sarcoplasmic Reticulum Myosin unbinds from actin causing muscle relaxation Decreased calcium is unable to bind readily to calmodulin so it does not activate myosin light chain kinase Activation of myosin light chain kinase leading to high concentration of myosin LC-P There is an overall decrease in calcium levels in the cytosol caused by the inhibition of the Gq signaling cascade Cytosol Smooth Muscle Myocyte Propantheline is an antagonist of the muscarinic acetylcholine receptor M1, this blocks acetylcholine action Actin Myosin Propantheline is administered as an oral tablet
GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 MYLK CHRM1 MYL3 MYL3 CALM1 PPP1CB CALM1 Inositol 1,4,5- trisphosphate Acetylcholine Propantheline Calcium Calcium Calcium Propantheline Phosphatidylinositol 4,5- bisphosphate Calcium Diacylglycerol Muscle Contraction Muscle Relaxation
GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 MYLK