Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 2B 5- hydroxytryptamine receptor 2C Sodium- dependent serotonin transporter Synaptic vesicular amine transporter Multidrug resistance protein 1 Solute carrier organic anion transporter family member 1B1 Solute carrier organic anion transporter family member 1B1 Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Cytochrome P450 2D6 Serotonin Desvenlafaxine Serotonin Serotonin Serotonin Na+ Na+ Desvenlafaxine Desvenlafaxine Venlafaxine Venlafaxine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Fe2+ Heme Increase in vagus nerve stimulation and electrical impulses suppression of depression and anxiety Pyridoxal 5'-phosphate Serotonin receptors 2A,B,C are responsible for a variety of cognitive abilities such as learning, appetite, anxiety, memory, mood and sleep. Desvenlafaxine is rapidly absorbed from the gastrointestinal tract. Presynaptic neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Synapse Desvenlfaxine inhibits the serotonin reuptake transporter, causing serotonin accumulation in the synaptic cleft Increasing activation of serotonin receptors increases stimulus for changes in downstream effects of these receptors affecting the mental state of the individual hepatocytes Liver endoplasmic reticulum Brain Serotonin is produced from the Raphei nucleus
Endoplasmic Reticulum HTR2A HTR2B HTR2C SLC6A4 SLC18A2 ABCB1 SLCO1B1 SLCO1B1 TPH1 DDC CYP2D6 Serotonin Desvenlafaxine Serotonin Serotonin Serotonin Sodium Sodium Desvenlafaxine Desvenlafaxine Venlafaxine Venlafaxine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Increase in vagus nerve stimulation and electrical impulses suppression of depression and anxiety