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Pathway Description
Desvenlafaxine SNRI - Norepinephrine reuptake Inhibition Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-07-03
Last Updated: 2023-11-27
The exact mechanism of action of venlafaxine in the treatment of various psychiatric conditions has not been fully elucidated; however, it is understood that venlafaxine and its active metabolite O-desmethylvenlafaxine (ODV) commonly called desvenlafaxine potently and selectively inhibits the reuptake of both serotonin and norepinephrine at the presynaptic terminal. This results in increased levels of neurotransmitters available at the synapse that can stimulate postsynaptic receptors. It is suggested that venlafaxine has a 30-fold selectivity for serotonin compared to norepinephrine: venlafaxine initially inhibits serotonin reuptake at low doses, and with higher doses, it inhibits norepinephrine reuptake in addition to serotonin. Venlafaxine and desvenlafaxine are also weak inhibitors of dopamine reuptake.
References
Desvenlafaxine SNRI - Norepinephrine reuptake Inhibition pathway References
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