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5-
hydroxytryptamine
receptor 2A
5-
hydroxytryptamine
receptor 2B
5-
hydroxytryptamine
receptor 2C
Sodium-
dependent
serotonin
transporter
Synaptic
vesicular amine
transporter
Multidrug
resistance
protein 1
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Serotonin
Duloxetine
Serotonin
Serotonin
Serotonin
Na
+
Na
+
Duloxetine
Duloxetine
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
Fe2+
Increase in
vagus nerve
stimulation and
electrical
impulses
suppression of
depression and
anxiety
Pyridoxal
5'-phosphate
The serotonin receptors
2A,B,C are responsible for a
variety of cognitive
abilities such as learning,
appetite, anxiety, memory,
mood and sleep.
Duloxetine is rapidly
absorbed from the
gastrointestinal tract.
Presynaptic neuron
Cytosol
Synaptic Vesicle
Postsynaptic Neuron
Cytosol
Synapse
Duloxetine inhibits the
serotonin reuptake
transporter, causing
serotonin accumulation in
the synaptic cleft
Increasing activation of
serotonin receptors can
increase stimulus for
changes in downstream
effects of these receptors
affecting the mental state
of the individual
Brain
Raphei nuclei
Blood vessel - Blood brain
barrier
HTR2A
HTR2B
HTR2C
SLC6A4
SLC18A2
ABCB1
TPH1
DDC
Serotonin
Duloxetine
Serotonin
Serotonin
Serotonin
Sodium
Sodium
Duloxetine
Duloxetine
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Increase in
vagus nerve
stimulation and
electrical
impulses
suppression of
depression and
anxiety
HTR2A
HTR2B
HTR2C
SLC6A4