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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 2B 5- hydroxytryptamine receptor 2C Sodium- dependent serotonin transporter Synaptic vesicular amine transporter Multidrug resistance protein 1 Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Serotonin Duloxetine Serotonin Serotonin Serotonin Na+ Na+ Duloxetine Duloxetine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Fe2+ Increase in vagus nerve stimulation and electrical impulses suppression of depression and anxiety Pyridoxal 5'-phosphate The serotonin receptors 2A,B,C are responsible for a variety of cognitive abilities such as learning, appetite, anxiety, memory, mood and sleep. Duloxetine is rapidly absorbed from the gastrointestinal tract. Presynaptic neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Synapse Duloxetine inhibits the serotonin reuptake transporter, causing serotonin accumulation in the synaptic cleft Increasing activation of serotonin receptors can increase stimulus for changes in downstream effects of these receptors affecting the mental state of the individual Brain Raphei nuclei Blood vessel - Blood brain barrier
HTR2A HTR2B HTR2C SLC6A4 SLC18A2 ABCB1 TPH1 DDC Serotonin Duloxetine Serotonin Serotonin Serotonin Sodium Sodium Duloxetine Duloxetine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Increase in vagus nerve stimulation and electrical impulses suppression of depression and anxiety
HTR2A HTR2B HTR2C SLC6A4