Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loader

Loading Pathway...

D(2) dopamine receptor D(4) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Solute carrier family 22 member 5 Sodium- dependent dopamine transporter Solute carrier family 22 member 5 Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Dopamine Aripiprazole Aripiprazole Ca+ Ca+ Dopamine Aripiprazole Aripiprazole Dopamine L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate GDP Gi signaling cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Norepinephrine is synthesized and stored in synaptic vesicles at the nerve terminal Aripiprazole is a partial agonist at D2 receptor. It competes with the endogenous dopamine for this receptor but only has partial efficacy when it binds to this receptor, thus reducing dopamine signaling ↓ Positive, negative and cognitive symptoms of schizophrenia Aripiprazole will act as a functional antagonist in areas of high dopamine, such as the mesolimbic pathway Aripiprazole has a high affinity for D2, D3 receptors and moderate affinity for D4 receptors Brain Mesolimbic pathway Aripiprazole is non functional in the nigrostriatal and tuberoinfundibular pathways Blood vessel - blood brain barrier Aripiprazole is taken orally and absorbed from the gastrointestinal tract.
DRD2 DRD4 CACNA1A CACNB1 CACNA2D2 SLC22A5 SLC6A3 SLC22A5 SLC18A2 DDC TH GNAS Dopamine Aripiprazole Aripiprazole Calcium Calcium Dopamine Aripiprazole Aripiprazole Dopamine L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Guanosine diphosphate Gi signaling cascade
DRD2 DRD4 CACNA1A CACNB1 CACNA2D2 SLC22A5 SLC6A3 SLC22A5 SLC18A2 DDC TH GNAS LDP Abilify Abilify Ca+ Ca+ LDP Abilify Abilify LDP L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P GDP Gi si c Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Norepinephrine is synthesized and stored in synaptic vesicles at the nerve terminal Aripiprazole is a partial agonist at D2 receptor. It competes with the endogenous dopamine for this receptor but only has partial efficacy when it binds to this receptor, thus reducing dopamine signaling ↓ Positive, negative and cognitive symptoms of schizophrenia Aripiprazole will act as a functional antagonist in areas of high dopamine, such as the mesolimbic pathway Aripiprazole has a high affinity for D2, D3 receptors and moderate affinity for D4 receptors Brain Mesolimbic pathway Aripiprazole is non functional in the nigrostriatal and tuberoinfundibular pathways Blood vessel - blood brain barrier Aripiprazole is taken orally and absorbed from the gastrointestinal tract.