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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 1A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Solute carrier family 22 member 5 Solute carrier family 22 member 5 Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Aripiprazole Aripiprazole Ca+ Serotonin Aripiprazole Aripiprazole L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Gi signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ Negative symptoms of schizophrenia Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Aripiprazole is a weak partial agonist at 5HT2A where it acts as a functional antagonist to reduce negative symptoms of schizophrenia Aripiprazole agonism at 5HT1A receptors are responsible for treating for of the cognitive improvement in schizophrenia ↑Cognitive Improvement Brain Raphei nuclei producing serotonergic neurons Blood vessel - blood brain barrier Aripiprazole is taken orally and absorbed from the gastrointestinal tract.
HTR2A HTR1A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 SLC22A5 SLC22A5 TPH1 DDC Calcium Serotonin Serotonin Aripiprazole Aripiprazole Calcium Serotonin Aripiprazole Aripiprazole L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Gq signaling cascade Gi signaling cascade
HTR2A HTR1A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 SLC22A5 SLC22A5 TPH1 DDC Ca+ 5-HT 5-HT Abilify Abilify Ca+ 5-HT Abilify Abilify Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Fe2+ Pyr-5'P Gq si c Gi si c