Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
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D(2) dopamine receptor D(3) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Vesicle- associated membrane protein 2 Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ropinirole Ropinirole Ca+ Ca+ Dopamine Ropinirole Ropinirole Dopamine L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi Signaling Cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Ropinirole is an agonist at D2 receptor. it increases dopamine availability Neuronal excitability Ropinirole has a high affinity for D2, D3 receptors and moderate affinity for D4 receptors Brain Nigrostriatal pathway Ropinirole is functional in the mesolimbic and tuberoinfundibular pathways Blood vessel - blood brain barrier Passive Diffusion Caudate-Putamen
DRD2 DRD3 CACNA1A CACNB1 CACNA2D2 SLC6A3 VAMP2 DDC TH Dopamine Ropinirole Ropinirole Calcium Calcium Dopamine Ropinirole Ropinirole Dopamine L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi Signaling Cascade
DRD2 DRD3 CACNA1A CACNB1 CACNA2D2 SLC6A3 VAMP2 DDC TH LDP Ropin Ropin Ca+ Ca+ LDP Ropin Ropin LDP L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi Si C Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Ropinirole is an agonist at D2 receptor. it increases dopamine availability Neuronal excitability Ropinirole has a high affinity for D2, D3 receptors and moderate affinity for D4 receptors Brain Nigrostriatal pathway Ropinirole is functional in the mesolimbic and tuberoinfundibular pathways Blood vessel - blood brain barrier Passive Diffusion Caudate-Putamen
DRD2 DRD3 CACNA1A CACNB1 CACNA2D2 SLC6A3 VAMP2 DDC TH LDP Ropin Ropin Ca2+ Ca2+ LDP Ropin Ropin LDP L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Gi Si C