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P2Y
purinoceptor 12
Gαi
Adenylate
Cyclase
Plasma membrane
Ca-ADPase
Multidrug
resistance
protein 1
Cytochrome P450
2C19
Cytochrome P450
2B6
Cytochrome P450
2C19
Cytochrome P450
3A4
Cytochrome P450
2B6
Cytochrome P450
2C9
Cytochrome P450
3A5
Serum
paraoxonase/arylesterase
1
Cytochrome P450
1A2
ADP
cAMP
Active Metabolite of Clopidogrel
Ca
+
Ca
+
Clopidogrel
Clopidogrel
Active Metabolite of
Clopidogrel
O
2
H
2
O
2-Oxoclopidogrel
H
2
O
2
Magnesium
cAMP
Clopidogrel