Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loader

Loading Pathway...

P2Y purinoceptor 12 Gαi Adenylate Cyclase Plasma membrane Ca-ADPase Multidrug resistance protein 1 Cytochrome P450 2C19 Cytochrome P450 2B6 Cytochrome P450 2C19 Cytochrome P450 3A4 Cytochrome P450 2B6 Cytochrome P450 2C9 Cytochrome P450 3A5 Serum paraoxonase/arylesterase 1 Cytochrome P450 1A2 ADP cAMP Active Metabolite of Clopidogrel Ca+ Ca+ Clopidogrel Clopidogrel Active Metabolite of Clopidogrel O2 H2O 2-Oxoclopidogrel H2O2 Magnesium cAMP Clopidogrel The active metabolite of clopidogrel has high affinity for the P2Y12 receptor to which it binds reversibly, preventing binding of ADP. Gi protein no longer inhibits adenylate cyclase, leading to a buildup of cAMP activating calcium efflux pump and prevents platelet activation Normally, ADP binds to P2Y12, activating the coupled Gi protein, inhibiting adenylate cyclase and leading to a shortage of cAMP. Calcium efflux is inactivated by lack of cAMP, inducing platelet activation and aggregation. Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Blood Vessel or Cell Damage Clopidogrel is administered orally, through first pass metabolism into active metabolites Blood Vessel Endoplasmic Reticulum Clopidogrel is a prodrug and through first pass metabolism, it is converted to its active form Hepatocyte
Melanosome Chloroplast Chloroplast Endoplasmic Reticulum P2RY12 GNAI1 ADCY10 Unknown ABCB1 CYP2C19 CYP2B6 CYP2C19 CYP3A4 CYP2B6 CYP2C9 CYP3A5 PON1 CYP1A2 Adenosine diphosphate cAMP Active Metabolite of Clopidogrel Calcium Calcium Clopidogrel Clopidogrel Active Metabolite of Clopidogrel Oxygen Water 2- Oxoclopidogrel Hydrogen peroxide Clopidogrel
P2RY12 GNAI1 ADCY10 ABCB1 CYP2C19 CYP2B6 CYP2C19 CYP3A4 CYP2B6 CYP2C9 CYP3A5 PON1 CYP1A2 ADP cAMP AMClop Ca+ Ca+ Clopid Clopid AMClop O2 H2O 2Oxocpg H2O2 Mg2+ cAMP Clopid The active metabolite of clopidogrel has high affinity for the P2Y12 receptor to which it binds reversibly, preventing binding of ADP. Gi protein no longer inhibits adenylate cyclase, leading to a buildup of cAMP activating calcium efflux pump and prevents platelet activation Normally, ADP binds to P2Y12, activating the coupled Gi protein, inhibiting adenylate cyclase and leading to a shortage of cAMP. Calcium efflux is inactivated by lack of cAMP, inducing platelet activation and aggregation. Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Blood Vessel or Cell Damage Clopidogrel is administered orally, through first pass metabolism into active metabolites Blood Vessel Endoplasmic Reticulum Clopidogrel is a prodrug and through first pass metabolism, it is converted to its active form Hepatocyte
Melanosome Chloroplast Chloroplast Endoplasmic Reticulum P2RY12 GNAI1 ADCY10 ABCB1 CYP2C19 CYP2B6 CYP2C19 CYP3A4 CYP2B6 CYP2C9 CYP3A5 PON1 CYP1A2 ADP cAMP AMClop Ca2+ Ca2+ Clopid Clopid AMClop O2 H2O 2Oxocpg H2O2 Clopid