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5-
hydroxytryptamine
receptor 2A
5-
hydroxytryptamine
receptor 1A
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Synaptic
vesicular amine
transporter
Sodium-
dependent
serotonin
transporter
Solute carrier
family 22
member 1
Solute carrier
family 22
member 1
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Ca
+
Serotonin
Serotonin
Ziprasidone
Ziprasidone
Ca
+
Serotonin
Ziprasidone
Ziprasidone
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
Na
+
Na
+
Fe2+
Pyridoxal
5'-phosphate
Gq signaling
cascade
Gi signaling
cascade
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ Negative symptoms of
schizophrenia
Serotonin is synthesized and
stored in synaptic vesicles
at the nerve terminal
Ziprasidone binds to 5HT2A
where it acts as a
functional antagonist to
reduce negative symptoms of
schizophrenia
Ziprasidone agonism at 5HT1A
receptors are responsible
for treating for of the
cognitive improvement in
schizophrenia
↑Cognitive Improvement
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
Ziprasidone also acts as an
antagonist to 5HT2C and
5HTID receptors which
contribute to its
antidepressant and
anxiolytic properties
Ziprasidone is taken orally
and absorbed from the
gastrointestinal tract
HTR2A
HTR1A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
SLC22A1
SLC22A1
TPH1
DDC
Calcium
Serotonin
Serotonin
Ziprasidone
Ziprasidone
Calcium
Serotonin
Ziprasidone
Ziprasidone
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Sodium
Sodium
Gq signaling
cascade
Gi signaling
cascade
HTR2A
HTR1A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
SLC22A1
SLC22A1
TPH1
DDC
Ca
+
5-HT
5-HT
Ziprasi
Ziprasi
Ca
+
5-HT
Ziprasi
Ziprasi
Trp
BH4
O
2
5-HTP
4aHtHbp
CO
2
Na
+
Na
+