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Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit epsilon-2 Glutamate [NMDA] receptor subunit 3A Vesicular glutamate transporter 3 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glutaminase kidney isoform, mitochondrial L-Glutamic acid Ca+ L-Glutamic acid Ketamine L-Glutamine Ca+ Ca+ L-Glutamic acid Ca+ Ketamine Ketamine H2O NH3 Glutamate Metabolism Hyperpolarization Cytosol Ketamine non-selectively and non-competitively binds to the Glutamate NMDA receptor subunit 2 which prevents Glutamate from binding and activating the receptor. This prevents depolarization Postsynaptic Neuron The low concentration of calcium in the postsynaptic neuron causes hyperpolarization, which increases the membrane potential threshold, preventing depolarization Presynaptic Neuron Cytosol Glutamate can be synthesized in the neuron or often is synthesized in adjacent glial cells Synaptic Vesicle Synapse Ketamine is injected intravenously Blood-Brain Barrier
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS L-Glutamic acid Calcium L-Glutamic acid Ketamine L-Glutamine Calcium Calcium L-Glutamic acid Calcium Ketamine Ketamine Water Ammonia Glutamate Metabolism Hyperpolarization
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS Glu Ca+ Glu Nmda Gln Ca+ Ca+ Glu Ca+ Nmda Nmda H2O NH3 PW000003 Hyper Cytosol Ketamine non-selectively and non-competitively binds to the Glutamate NMDA receptor subunit 2 which prevents Glutamate from binding and activating the receptor. This prevents depolarization Postsynaptic Neuron The low concentration of calcium in the postsynaptic neuron causes hyperpolarization, which increases the membrane potential threshold, preventing depolarization Presynaptic Neuron Cytosol Glutamate can be synthesized in the neuron or often is synthesized in adjacent glial cells Synaptic Vesicle Synapse Ketamine is injected intravenously Blood-Brain Barrier
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS Glu Ca2+ Glu Nmda Gln Ca2+ Ca2+ Glu Ca2+ Nmda Nmda H2O NH3 PW000003 Hyper