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D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Solute carrier family 12 member 3 Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Dopamine Ca+ Thiethylperazine Ca+ Dopamine Dopamine Thiethylperazine Thiethylperazine L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate GDP Gi signaling cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Thiethylperazine is a D2 receptor antagonist. D2 receptors in the mesolimbic pathway are responsible for producing symptoms in psychosis antipsychotic effect Brain Mesolimbic pathway Blood vessel - blood brain barrier antiemetic effect Thiethylperazine is taken orally and absorbed from the gastrointestinal tract
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 SLC12A3 DDC TH GNAS Dopamine Calcium Thiethylperazine Calcium Dopamine Dopamine Thiethylperazine Thiethylperazine L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Guanosine diphosphate Gi signaling cascade
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 SLC12A3 DDC TH GNAS LDP Ca+ Tietilp Ca+ LDP LDP Tietilp Tietilp L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P GDP Gi si c Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Thiethylperazine is a D2 receptor antagonist. D2 receptors in the mesolimbic pathway are responsible for producing symptoms in psychosis antipsychotic effect Brain Mesolimbic pathway Blood vessel - blood brain barrier antiemetic effect Thiethylperazine is taken orally and absorbed from the gastrointestinal tract
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 SLC12A3 DDC TH GNAS LDP Ca2+ Tietilp Ca2+ LDP LDP Tietilp Tietilp L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ GDP Gi si c