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Pathway Description
Thiethylperazine Dopamine Antagonist Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-07-13
Last Updated: 2023-11-27
Thiethylperazine is in the class of the piperazine - phenothiazines which are a class of first generation antipsychotic medications. Phenothiazines are generally dopamine receptor antagonists. Thiethylperazine' s antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Thiethylperazine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. It is a sedating antihistamine used as an antiemetic agent for the control of nausea and vomiting associated with surgical procedures.
References
Thiethylperazine Dopamine Antagonist Pathway References
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Pubmed: 8528245
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