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5-
hydroxytryptamine
receptor 2A
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Synaptic
vesicular amine
transporter
Sodium-
dependent
serotonin
transporter
Solute carrier
family 12
member 3
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Ca
+
Serotonin
Serotonin
Thiethylperazine
Ca
+
Serotonin
Thiethylperazine
Thiethylperazine
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
Na
+
Na
+
Fe2+
Pyridoxal
5'-phosphate
Gq signaling
cascade
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ psychotic effects
Serotonin is synthesized and
stored in synaptic vesicles
at the nerve terminal
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
Thiethylperazine also acts
as an antagonist to 5HT2C,
Dopamine 1,2,4 receptor
types, M1- M5, alpha (1) and
H1 receptors
Thiethylperazine is taken
orally and absorbed from the
gastrointestinal tract
HTR2A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
SLC12A3
TPH1
DDC
Calcium
Serotonin
Serotonin
Thiethylperazine
Calcium
Serotonin
Thiethylperazine
Thiethylperazine
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Sodium
Sodium
Gq signaling
cascade
HTR2A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
SLC12A3
TPH1
DDC
Ca
+
5-HT
5-HT
Tietilp
Ca
+
5-HT
Tietilp
Tietilp
Trp
BH4
O
2
5-HTP
4aHtHbp
CO
2
Na
+
Na
+
Fe2+
Pyr-5'P
Gq si c
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ psychotic effects
Serotonin is synthesized and
stored in synaptic vesicles
at the nerve terminal
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
Thiethylperazine also acts
as an antagonist to 5HT2C,
Dopamine 1,2,4 receptor
types, M1- M5, alpha (1) and
H1 receptors
Thiethylperazine is taken
orally and absorbed from the
gastrointestinal tract