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D(2) dopamine
receptor
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Sodium-
dependent
dopamine
transporter
Synaptic
vesicular amine
transporter
Aromatic-L-
amino-acid
decarboxylase
Tyrosine
3-monooxygenase
Dopamine
Ca
+
Remoxipride
Ca
+
Dopamine
Dopamine
Remoxipride
L-Dopa
CO
2
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
Na
+
Na
+
Pyridoxal
5'-phosphate
Gi signaling
cascade
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Remoxipiride is a D2
receptor antagonist. It also
acts as an antagonist to D3,
D4, 5HT2A and sigma
non-opioid intracellular
receptor 1
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Excess dopamine in the brain
triggers positive symptoms
of schizophrenia
Brain
Mesolimbic pathway
Blood vessel - blood brain
barrier
passive diffusion
Remoxipride is taken orally
and absorbed from the
gastrointestinal tract
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
Dopamine
Calcium
Remoxipride
Calcium
Dopamine
Dopamine
Remoxipride
L-Dopa
Carbon dioxide
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
Sodium
Sodium
Gi signaling
cascade
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
LDP
Ca
+
Roxiam
Ca
+
LDP
LDP
Roxiam
L-Dopa
CO
2
Tyr
BH4
O
2
BH3
H
2
O
Na
+
Na
+
Pyr-5'P
Gi si c
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Remoxipiride is a D2
receptor antagonist. It also
acts as an antagonist to D3,
D4, 5HT2A and sigma
non-opioid intracellular
receptor 1
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Excess dopamine in the brain
triggers positive symptoms
of schizophrenia
Brain
Mesolimbic pathway
Blood vessel - blood brain
barrier
passive diffusion
Remoxipride is taken orally
and absorbed from the
gastrointestinal tract