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D(2) dopamine
receptor
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Sodium-
dependent
dopamine
transporter
Synaptic
vesicular amine
transporter
Aromatic-L-
amino-acid
decarboxylase
Tyrosine
3-monooxygenase
Dopamine
Ca
+
Droperidol
Ca
+
Dopamine
Dopamine
Droperidol
L-Dopa
CO
2
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
Na
+
Na
+
Pyridoxal
5'-phosphate
Gi signaling
cascade
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Droperidol is a D2 and Alpha
1A adrenergic receptor
antagonist.
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Droperidol is an antagonist
to dopamine receptor D2
present in the
chemoreceptors trigger zone
(CTZ). The receptors in the
CTZ, when stimulated give
rise to pathways leading to
nausea and vomiting.
Brain
Mesolimbic pathway
Blood Brain Barrier
Droperidol is injected
intravenously and
intramuscularly. It readily
diffuses into the brain via
lipid mediated diffusion.
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
Dopamine
Calcium
Droperidol
Calcium
Dopamine
Dopamine
Droperidol
L-Dopa
Carbon dioxide
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
Sodium
Sodium
Gi signaling
cascade
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
LDP
Ca
+
Droperi
Ca
+
LDP
LDP
Droperi
L-Dopa
CO
2
Tyr
BH4
O
2
BH3
H
2
O
Na
+
Na
+
Pyr-5'P
Gi si c
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Droperidol is a D2 and Alpha
1A adrenergic receptor
antagonist.
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Droperidol is an antagonist
to dopamine receptor D2
present in the
chemoreceptors trigger zone
(CTZ). The receptors in the
CTZ, when stimulated give
rise to pathways leading to
nausea and vomiting.
Brain
Mesolimbic pathway
Blood Brain Barrier
Droperidol is injected
intravenously and
intramuscularly. It readily
diffuses into the brain via
lipid mediated diffusion.