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D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Droperidol Ca+ Dopamine Dopamine Droperidol L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi signaling cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Droperidol is a D2 and Alpha 1A adrenergic receptor antagonist. ↓ Positive, negative and cognitive symptoms of schizophrenia Droperidol is an antagonist to dopamine receptor D2 present in the chemoreceptors trigger zone (CTZ). The receptors in the CTZ, when stimulated give rise to pathways leading to nausea and vomiting. Brain Mesolimbic pathway Blood Brain Barrier Droperidol is injected intravenously and intramuscularly. It readily diffuses into the brain via lipid mediated diffusion.
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH Dopamine Calcium Droperidol Calcium Dopamine Dopamine Droperidol L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi signaling cascade
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Droperi Ca+ LDP LDP Droperi L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi si c Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Droperidol is a D2 and Alpha 1A adrenergic receptor antagonist. ↓ Positive, negative and cognitive symptoms of schizophrenia Droperidol is an antagonist to dopamine receptor D2 present in the chemoreceptors trigger zone (CTZ). The receptors in the CTZ, when stimulated give rise to pathways leading to nausea and vomiting. Brain Mesolimbic pathway Blood Brain Barrier Droperidol is injected intravenously and intramuscularly. It readily diffuses into the brain via lipid mediated diffusion.