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5-
hydroxytryptamine
receptor 2A
5-
hydroxytryptamine
receptor 1A
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Synaptic
vesicular amine
transporter
Sodium-
dependent
serotonin
transporter
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Ca
+
Serotonin
Serotonin
Chlorpromazine
Chlorpromazine
Ca
+
Serotonin
Chlorpromazine
Chlorpromazine
Chlorpromazine
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
Na
+
Na
+
Fe2+
Pyridoxal
5'-phosphate
Gq signaling
cascade
Gi signaling
cascade
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ Negative symptoms of
schizophrenia
Serotonin is synthesized at
the raphei nuclei and stored
in synaptic vesicles at the
nerve terminal
Chlorpromazine binds to
5HT1A and 5HT2A where it
acts as a functional
antagonist to reduce
negative symptoms of
schizophrenia
↑Cognitive Improvement
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
Chlorpromazine also acts as
an antagonist to D1 - D5,
Alpha -1A, Alpha - 1B and
H1, H4, 5HT2C receptors
passive diffusion
Passive diffusion
Chlorpromazine is taken
orally
HTR2A
HTR1A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
TPH1
DDC
Calcium
Serotonin
Serotonin
Chlorpromazine
Chlorpromazine
Calcium
Serotonin
Chlorpromazine
Chlorpromazine
Chlorpromazine
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Sodium
Sodium
Gq signaling
cascade
Gi signaling
cascade
HTR2A
HTR1A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
TPH1
DDC
Ca
+
5-HT
5-HT
Cpz
Cpz
Ca
+
5-HT
Cpz
Cpz
Cpz
Trp
BH4
O
2
5-HTP
4aHtHbp