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Pathway Description
Fludarabine Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-07-17
Last Updated: 2023-11-27
Fludarabine, also known as Fludara, is a purine analog (antimetabolite) used as a chemotherapeutic drug. This molecule is used in the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with one alkylating agent. Fludarabine acts as an inhibitor of the DNA polymerase and ribonucleoside-diphosphate reductase. After entering the cell via the equilibration nucleoside transporter and the sodium/nucleoside cotransporter, the drug is phosphorylated to 2-fluoro-ara-A and then phosphorylated by the deoxycytidine kinase to the active triphosphate metabolite: 2-fluoro-ara-ATP. This metabolite will bind and inhibit the DNA polymerase on its catalytic subunit and the ribonucleotide reductase, inhibiting DNA synthesis. The drug, fludarabine, may also inhibit the DNA ligase and primase. This chemotherapeutic agent is administered as an intravenous injection.
References
Fludarabine Pathway References
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