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Adenylate Cyclase Plasma membrane Ca-ADPase G protein complex Prostaglandin D2 receptor Intermediate conductance calcium- activated potassium channel protein 4 Prostacyclin receptor P2Y purinoceptor 12 ADP cAMP Treprostinil Ca+ Ca+ Treprostinil Treprostinil K+ K+ Magnesium cAMP Treprostinil binds as an agonist to P2Y12, prostacyclin and prostaglandin D2 receptors. Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Blood Vessel or Cell Damage Treprostinil is administered subcutaneously and travels through the bloodstream Blood Vessel This activation subsequently increasing cAMP levels. High cAMP levels activates calcium channels causing calcium needed for platelet activation and aggregation being released from the cell and inhibiting the process. Calcium in the extracellular space then goes to act on potassium channels which hyper polarizes the cell and stops aggregation.
Melanosome Chloroplast Chloroplast ADCY10 Unknown GNG2 PTGDR KCNN4 PTGIR P2RY12 Adenosine diphosphate cAMP Treprostinil Calcium Calcium Treprostinil Treprostinil Potassium Potassium
ADCY10 GNG2 PTGDR KCNN4 PTGIR P2RY12 ADP cAMP Trepros Ca+ Ca+ Trepros Trepros K+ K+ Mg2+ cAMP Treprostinil binds as an agonist to P2Y12, prostacyclin and prostaglandin D2 receptors. Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Blood Vessel or Cell Damage Treprostinil is administered subcutaneously and travels through the bloodstream Blood Vessel This activation subsequently increasing cAMP levels. High cAMP levels activates calcium channels causing calcium needed for platelet activation and aggregation being released from the cell and inhibiting the process. Calcium in the extracellular space then goes to act on potassium channels which hyper polarizes the cell and stops aggregation.
Melanosome Chloroplast Chloroplast ADCY10 GNG2 PTGDR KCNN4 PTGIR P2RY12 ADP cAMP Trepros Ca2+ Ca2+ Trepros Trepros K+ K+