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3-oxo-5- alpha-steroid 4-dehydrogenase 2 Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 17-alpha- hydroxylase/17,20 lyase Aldo-keto reductase family 1 member C3 3 beta- hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 Testosterone 17-beta- dehydrogenase 3 3-beta-HSD 1 Androgen receptor Androgen receptor Androgen receptor Dutasteride Cholesterol Pregnenolone Dutasteride Dutasteride FMNH2 O2 17a-Hydroxypregnenolone Flavin Mononucleotide H2O FMNH2 O2 Dehydroepiandrosterone Acetic acid Flavin Mononucleotide H2O NADH H+ 5-Androstenediol NAD NAD Testosterone NADH H+ NADP Androstenedione NADPH H+ Dehydroepiandrosterone NAD NADH H+ NADPH H+ Dihydrotestosterone NADP Dihydrotestosterone Dihydrotestosterone Prostaglandin D2 Promoter Steroidogenesis Prostaglandin D2 receptor Heme Heme Endoplasmic Reticulum Cytosol Dutasteride inhibits type I and type II 5α-reductase, which convert the androgen testosterone into the more active metabolite, 5α-dihydrotestosterone. Prostatic stromal cell Blood Vessel Nucleus Dihydrotestosterone promotes the transcription rate of many genes. Among others, there is the prostaglandin D2 gene. In consequence, since it is in low concentration, less of this prostaglandin D2 will be produced and, thus, this will not be able to promote the proliferation of prostate cells. The low concentration of dihydrotestosterone slow the cell proliferation, permits hair regrowth and a slower hair lost.
Endoplasmic Reticulum Nucleus SRD5A2 CYP17A1 CYP17A1 AKR1C3 HSD3B1 HSD17B3 HSD3B1 AR AR AR Dutasteride Cholesterol Pregnenolone Dutasteride Dutasteride FMNH2 Oxygen 17a- Hydroxypregnenolone Flavin Mononucleotide Water FMNH2 Oxygen Dehydroepiandrosterone Acetic acid Flavin Mononucleotide Water NADH Hydrogen Ion 5- Androstenediol NAD NAD Testosterone NADH Hydrogen Ion NADP Androstenedione NADPH Hydrogen Ion Dehydroepiandrosterone NAD NADH Hydrogen Ion NADPH Hydrogen Ion Dihydrotestosterone NADP Dihydrotestosterone Dihydrotestosterone Prostaglandin D2 Promoter Steroidogenesis PTGDR
SRD5A2 CYP17A1 CYP17A1 AKR1C3 HSD3B1 HSD17B3 HSD3B1 AR AR AR Dutaste Lanol Pregnen Dutaste Dutaste FMNH2 O2 17a-HP FlvnMnt H2O FMNH2 O2 DHEA Acoh FlvnMnt H2O NADH H+ Tetrabo NAD NAD Oreton NADH H+ NADP Adione NADPH H+ DHEA NAD NADH H+ NADPH H+ DHT NADP DHT DHT Pros D2 P PW000141 PTGDR Heme Heme Endoplasmic Reticulum Cytosol Dutasteride inhibits type I and type II 5α-reductase, which convert the androgen testosterone into the more active metabolite, 5α-dihydrotestosterone. Prostatic stromal cell Blood Vessel Nucleus Dihydrotestosterone promotes the transcription rate of many genes. Among others, there is the prostaglandin D2 gene. In consequence, since it is in low concentration, less of this prostaglandin D2 will be produced and, thus, this will not be able to promote the proliferation of prostate cells. The low concentration of dihydrotestosterone slow the cell proliferation, permits hair regrowth and a slower hair lost.
Endoplasmic Reticulum Nucleus SRD5A2 CYP17A1 CYP17A1 AKR1C3 HSD3B1 HSD17B3 HSD3B1 AR AR AR Dutaste Lanol Pregnen Dutaste Dutaste FMNH2 O2 17a-HP FlvnMnt H2O FMNH2 O2 DHEA Acoh FlvnMnt H2O NADH H+ Tetrabo NAD NAD Oreton NADH H+ NADP Adione NADPH H+ DHEA NAD NADH H+ NADPH H+ DHT NADP DHT DHT Pros D2 P PW000141 PTGDR