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3-oxo-5-
alpha-steroid
4-dehydrogenase
2
Steroid
17-alpha-
hydroxylase/17,20
lyase
Steroid
17-alpha-
hydroxylase/17,20
lyase
Aldo-keto
reductase
family 1 member
C3
3 beta-
hydroxysteroid
dehydrogenase/Delta
5-->4-isomerase
type 1
Testosterone
17-beta-
dehydrogenase 3
3-beta-HSD 1
Androgen
receptor
Androgen
receptor
Androgen
receptor
Dutasteride
Cholesterol
Pregnenolone
Dutasteride
Dutasteride
FMNH2
O
2
17a-Hydroxypregnenolone
Flavin Mononucleotide
H
2
O
FMNH2
O
2
Dehydroepiandrosterone
Acetic acid
Flavin Mononucleotide
H
2
O
NADH
H
+
5-Androstenediol
NAD
NAD
Testosterone
NADH
H
+
NADP
Androstenedione
NADPH
H
+
Dehydroepiandrosterone
NAD
NADH
H
+
NADPH
H
+
Dihydrotestosterone
NADP
Dihydrotestosterone
Dihydrotestosterone
Prostaglandin D2
Promoter
Steroidogenesis
Prostaglandin
D2 receptor
Heme
Heme
Endoplasmic Reticulum
Cytosol
Dutasteride inhibits type I
and type II 5α-reductase,
which convert the androgen
testosterone into the more
active metabolite,
5α-dihydrotestosterone.
Prostatic stromal cell
Blood Vessel
Nucleus
Dihydrotestosterone promotes
the transcription rate of
many genes. Among others,
there is the prostaglandin
D2 gene. In consequence,
since it is in low
concentration, less of this
prostaglandin D2 will be
produced and, thus, this
will not be able to promote
the proliferation of
prostate cells.
The low concentration of
dihydrotestosterone slow the
cell proliferation, permits
hair regrowth and a slower
hair lost.
Endoplasmic Reticulum
Nucleus
SRD5A2
CYP17A1
CYP17A1
AKR1C3
HSD3B1
HSD17B3
HSD3B1
AR
AR
AR
Dutasteride
Cholesterol
Pregnenolone
Dutasteride
Dutasteride
FMNH2
Oxygen
17a-
Hydroxypregnenolone
Flavin
Mononucleotide
Water
FMNH2
Oxygen
Dehydroepiandrosterone
Acetic acid
Flavin
Mononucleotide
Water
NADH
Hydrogen Ion
5-
Androstenediol
NAD
NAD
Testosterone
NADH
Hydrogen Ion
NADP
Androstenedione
NADPH
Hydrogen Ion
Dehydroepiandrosterone
NAD
NADH
Hydrogen Ion
NADPH
Hydrogen Ion
Dihydrotestosterone
NADP
Dihydrotestosterone
Dihydrotestosterone
Prostaglandin
D2
Promoter
Steroidogenesis
PTGDR