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Pathway Description
Etonogestrel Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-07-20
Last Updated: 2023-11-27
Etonogestrel is a synthetic metabolite of progestin desosgestrel. This drug is a long-acting progestin contraceptive used mostly in intradermal implants that are releasing 40 mcg/day of the drug for 3 years. Etonogestrel binds strongly to the progesterone receptor in the mammary gland, the hypothalamus, and the pituitary. By those binding, this drug reduces the secretion of GnRH from the hypothalamus, resulting in the decrease of the synthesis of certain proteins. Among others, the rate of synthesis of the luteinizing hormone (LH) is decreased. The luteinizing hormone is one of the most important reproductive hormones for ovulation, its surge provokes the release of the eff. This drug also increases the viscosity of the cervical mucus. This blocks the passage of spermatozoa and alters the lining of the uterus to prevent the implantation of a fertilized egg in the endometrium.
References
Etonogestrel Pathway References
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Pubmed: 22935222
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