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Pathway Description
Drospirenone Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-07-21
Last Updated: 2023-11-27
Drospirenone is a synthetic progestin commonly found in popular oral contraceptives like Yaz, Angeliq, and Loryna. This drug is also indicated to control acne, menopause-associated symptoms, and premenstrual dysphoric disorder (PMDD) when used with estrogens. Drospirenone inhibits ovulation by inhibiting the release of the Luteinizing Hormone (LH) and the Follicle-Stimulating Hormone (FSH) in the pituitary gland. The low levels of both hormones result in the suppression of the surge of estrogen the ovaries need to release the egg. At the same time, Drospirenone binds to androgen receptors. This helps to oppose the effects of naturally occurring androgens, inhibiting the binding of dihydrotestosterone (DHT) to its receptor, and preventing androgen synthesis in the ovaries, helping to treat acne and hirsutism. An overdose of this drug will lead to nausea or withdrawal bleeding, like other oral contraceptives.
References
Drospirenone Pathway References
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Pubmed: 18728832
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Pubmed: 3024157
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Pubmed: 3025870
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Pubmed: 3500022
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Pubmed: 3274893
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Pubmed: 2139411
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Pubmed: 9709959
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Pubmed: 8075637
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Pubmed: 2973313
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Pubmed: 2848247
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Pubmed: 2330005
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Pubmed: 22935222
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