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Pathway Description
Triflusal Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-07-25
Last Updated: 2023-11-27
Triflusal is a 2-acetoxy-4-trifluorobenzoic acid chemically related to acetylsalicylic acid. This drug has antithrombotic effects by inhibiting irreversibly the cycloxygenase-1 (COX-1) in the platelets. It is indicated as prophylaxis of thromboembolic disorders (prevention of strokes and myocardial infarction). Trifusal binds to the prostaglandin G/H synthase 1, this inhibits the production of thromboxane-B2 in cells. It also acts on many other cellular targets like NF kappa B, which is a gene expression regulatory factor for cycloxygenase-a and cytokines. In addition, this drug induces the production of nitric oxide by binding as an agonist to the nitric oxide synthase. The high level of nitric oxide results in vasodilatation. Trifusal is administered as an oral tablet.
References
Triflusal Pathway References
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Pubmed: 2512924
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Pubmed: 8181472
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Pubmed: 1380156
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Pubmed: 2345548
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Pubmed: 2990550
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Pubmed: 15461802
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