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Pathway Description
Trifluoperazine Dopamine Antagonist Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-07-26
Last Updated: 2023-11-27
Trifluoperazine is a trifluoro-methyl phenothiazine derivative. Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. It is indicated for the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
References
Trifluoperazine Dopamine Antagonist Pathway References
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