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D(2) dopamine receptor D(1A) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Chlorprothixene Chlorprothixene Ca+ Dopamine Dopamine Chlorprothixene Chlorprothixene Chlorprothixene L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi signaling cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Chlorprothixene is a D1 - D3 receptor antagonist. Dopamine receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia ↓ Positive, negative and cognitive symptoms of schizophrenia and psychosis Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Passive Diffusion Chlorprothixene is taken orally and absorbed through the gastrointestinal tract.
DRD2 DRD1 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH Dopamine Calcium Chlorprothixene Chlorprothixene Calcium Dopamine Dopamine Chlorprothixene Chlorprothixene Chlorprothixene L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi signaling cascade
DRD2 DRD1 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Chlothi Chlothi Ca+ LDP LDP Chlothi Chlothi Chlothi L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi si c Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Chlorprothixene is a D1 - D3 receptor antagonist. Dopamine receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia ↓ Positive, negative and cognitive symptoms of schizophrenia and psychosis Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Passive Diffusion Chlorprothixene is taken orally and absorbed through the gastrointestinal tract.