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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 1A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Acepromazine Acepromazine Ca+ Serotonin Acepromazine Acepromazine Acepromazine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Gi signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ Negative symptoms of schizophrenia and anxiety Serotonin is synthesized at the raphei nuclei and stored in synaptic vesicles at the nerve terminal Acepromazine binds to 5HT1A and 5HT2A where it reduces negative symptoms of schizophrenia, exhibits antidepressive and antiaggressive properties ↑Cognitive Improvement Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Acepromazine also acts as an antagonist to D1 - D4, Alpha -1 and 2 receptors. passive diffusion Passive diffusion Acepromazine is taken orally and absorbed from the gastrointestinal tract
HTR2A HTR1A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Acepromazine Acepromazine Calcium Serotonin Acepromazine Acepromazine Acepromazine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Gq signaling cascade Gi signaling cascade
HTR2A HTR1A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca+ 5-HT 5-HT Acetazi Acetazi Ca+ 5-HT Acetazi Acetazi Acetazi Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+