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5-
hydroxytryptamine
receptor 2A
5-
hydroxytryptamine
receptor 1A
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Synaptic
vesicular amine
transporter
Sodium-
dependent
serotonin
transporter
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Ca
+
Serotonin
Serotonin
Acepromazine
Acepromazine
Ca
+
Serotonin
Acepromazine
Acepromazine
Acepromazine
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
Na
+
Na
+
Fe2+
Pyridoxal
5'-phosphate
Gq signaling
cascade
Gi signaling
cascade
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ Negative symptoms of
schizophrenia and anxiety
Serotonin is synthesized at
the raphei nuclei and stored
in synaptic vesicles at the
nerve terminal
Acepromazine binds to 5HT1A
and 5HT2A where it reduces
negative symptoms of
schizophrenia, exhibits
antidepressive and
antiaggressive properties
↑Cognitive Improvement
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
Acepromazine also acts as an
antagonist to D1 - D4, Alpha
-1 and 2 receptors.
passive diffusion
Passive diffusion
Acepromazine is taken orally
and absorbed from the
gastrointestinal tract
HTR2A
HTR1A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
TPH1
DDC
Calcium
Serotonin
Serotonin
Acepromazine
Acepromazine
Calcium
Serotonin
Acepromazine
Acepromazine
Acepromazine
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Sodium
Sodium
Gq signaling
cascade
Gi signaling
cascade
HTR2A
HTR1A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
TPH1
DDC
Ca
+
5-HT
5-HT
Acetazi
Acetazi
Ca
+
5-HT
Acetazi
Acetazi
Acetazi
Trp
BH4
O
2
5-HTP
4aHtHbp
CO
2
Na
+