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Mitomycin Transporter NAD(P)H dehydrogenase [quinone] 1 Leuco-aziridinomitosene Adenine Mitomycin Leuco-aziridinomitosene NADPH Mitomycin Hydroquinone NADP Methanol FAD Mitomycin Adenine Alkylation Mitomycin is administered as an intravenous injection. It then goes in the cancerous cells via the circulatory system. After entering the cancerous cell, mitomycin is activated through two reactions. Firstly, mitomycin crosslinks DNA causing it to be unable to separate the strands for replication. Second,mitomycin induces the mispairing of nucleotide bases during replication causing mutations. This creates fraudulent DNA that cannot properly transcribe RNA. Third, mitomycin attachs alkyl groups to DNA bases, such as adenine in this reaction, which results in the DNA becoming fragmented due to repair enzymes trying to replace the alkylated bases. This preventing DNA synthesis and RNA transcription from affected DNA that has become alkylated. Apoptosis The cross-linking of bases and inhibition of DNA synthesis and function lead to the apoptosis of the cancerous cell. Cancerous Cell Mitomycin mostly treat cancers of the gastrointestinal tract: anal cancer, bladder cancer, gastric adenocarcinoma, mesothelioma, and many others. Nucleus The first reaction is the reduction to an hydroquinone. The second reaction, leading to the bioactivation of mitomycin, is the demethoxylation.
Nucleus Unknown NQO1 Leuco- aziridinomitosene Adenine Mitomycin Leuco- aziridinomitosene NADPH Mitomycin Hydroquinone NADP Methanol Mitomycin Adenine Alkylation
NQO1 Leu-azi Adenine Mmc Leu-azi NADPH Mit Hyd NADP MeOH FAD Mmc Ade Alk Mitomycin is administered as an intravenous injection. It then goes in the cancerous cells via the circulatory system. After entering the cancerous cell, mitomycin is activated through two reactions. Firstly, mitomycin crosslinks DNA causing it to be unable to separate the strands for replication. Second,mitomycin induces the mispairing of nucleotide bases during replication causing mutations. This creates fraudulent DNA that cannot properly transcribe RNA. Third, mitomycin attachs alkyl groups to DNA bases, such as adenine in this reaction, which results in the DNA becoming fragmented due to repair enzymes trying to replace the alkylated bases. This preventing DNA synthesis and RNA transcription from affected DNA that has become alkylated. Apoptosis The cross-linking of bases and inhibition of DNA synthesis and function lead to the apoptosis of the cancerous cell. Cancerous Cell Mitomycin mostly treat cancers of the gastrointestinal tract: anal cancer, bladder cancer, gastric adenocarcinoma, mesothelioma, and many others. Nucleus The first reaction is the reduction to an hydroquinone. The second reaction, leading to the bioactivation of mitomycin, is the demethoxylation.
Nucleus NQO1 Leu-azi Adenine Mmc Leu-azi NADPH Mit Hyd NADP MeOH Mmc Ade Alk