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Bendamustine Transporter Bendamustine Adenine Bendamustine Bendamustine Adenine Alkylation Mechlorethamine is absorbed from the skin. It then goes in the cancerous cells locally close. After entering the cancerous cell, bendamustine moves into the nucleus where it does 3 actions to inhibit DNA replication. Firstly, bendamustine crosslinks DNA causing it to be unable to separate the strands for replication. Second, bendamustine induces the mispairing of nucleotide bases during replication causing mutations. This creates fraudulent DNA that cannot properly transcribe RNA. Third,bendamustine attachs alkyl groups to DNA bases, such as adenine in this reaction, which results in the DNA becoming fragmented due to repair enzymes trying to replace the alkylated bases. This preventing DNA synthesis and RNA transcription from affected DNA that has become alkylated. Apoptosis The miscoding of the DNA, the cross-linking of guanine bases and the fragmentation of the DNA all lead to the apoptosis of the cancerous cell. Cancerous Cell
Nucleus Unknown Bendamustine Adenine Bendamustine Bendamustine Adenine Alkylation
Benda Adenine Benda Benda Ade Alk Mechlorethamine is absorbed from the skin. It then goes in the cancerous cells locally close. After entering the cancerous cell, bendamustine moves into the nucleus where it does 3 actions to inhibit DNA replication. Firstly, bendamustine crosslinks DNA causing it to be unable to separate the strands for replication. Second, bendamustine induces the mispairing of nucleotide bases during replication causing mutations. This creates fraudulent DNA that cannot properly transcribe RNA. Third,bendamustine attachs alkyl groups to DNA bases, such as adenine in this reaction, which results in the DNA becoming fragmented due to repair enzymes trying to replace the alkylated bases. This preventing DNA synthesis and RNA transcription from affected DNA that has become alkylated. Apoptosis The miscoding of the DNA, the cross-linking of guanine bases and the fragmentation of the DNA all lead to the apoptosis of the cancerous cell. Cancerous Cell
Nucleus Benda Adenine Benda Benda Ade Alk