Quantitative metabolomics services for biomarker discovery and validation.
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Sodium- dependent serotonin transporter 5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 2C Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Amitriptyline Serotonin Ca+ Serotonin Amitriptyline Amitriptyline L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse Mood Improvement Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Amitriptyline inhibits the serotonin reuptake transporter, thereby increasing synaptic serotonin Serotonin activates 5HT2A and 5HT2C receptors, which are responsible for mood improvements Blood-Brain Barrier Diffusion
SLC6A4 HTR2A HTR2C CACNA1A CACNB1 CACNA2D2 SLC18A2 TPH1 DDC Calcium Serotonin Amitriptyline Serotonin Calcium Serotonin Amitriptyline Amitriptyline L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Gq signaling cascade
SLC6A4 HTR2A HTR2C CACNA1A CACNB1 CACNA2D2 SLC18A2 TPH1 DDC Ca+ 5-HT Amitrip 5-HT Ca+ 5-HT Amitrip Amitrip Trp BH4 O2 5-HTP 4aHtHbp CO2 Fe2+ Pyr-5'P Gq si c Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse Mood Improvement Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Amitriptyline inhibits the serotonin reuptake transporter, thereby increasing synaptic serotonin Serotonin activates 5HT2A and 5HT2C receptors, which are responsible for mood improvements Blood-Brain Barrier Diffusion