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cAMP-dependent protein kinase type II-beta regulatory subunit cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit D(2) dopamine receptor Adenylate cyclase type 2 Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Synaptic vesicular amine transporter Voltage- dependent calcium channel subunit alpha-2/delta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent N-type calcium channel subunit alpha-1B Sodium- dependent dopamine transporter Tyrosine 3-monooxygenase Aromatic-L- amino-acid decarboxylase cAMP Ca+ Dopamine Dopamine Pergolide Dopamine Ca+ Pergolide Pergolide L-Tyrosine L-Dopa CO2 ATP PPi Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Neuronal Excitability Magnesium Activation of D2 dopamine receptors activates the Gi signalling cascade which leads to increased cAMP. Pergolide is an agonist at D1 - D5 receptors Presynaptic Neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Dopamine is produced in the Ventral Tegmental Area of the brain Nigrostriatal pathway Synapse Blood vessel - Blood Brain Barrier Brain passive diffusion Pergolide is taken orally and absorbed via the gastrointestinal tract
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY2 GNAS SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 TH DDC cAMP Calcium Dopamine Dopamine Pergolide Dopamine Calcium Pergolide Pergolide L-Tyrosine L-Dopa Carbon dioxide Adenosine triphosphate Pyrophosphate Sodium Sodium Neuronal Excitability
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY2 GNAS SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 TH DDC cAMP Ca+ LDP LDP Pergoli LDP Ca+ Pergoli Pergoli Tyr L-Dopa CO2 ATP PPi Na+ Na+ Fe2+ Pyr-5'P Neu Exc Mg2+ Activation of D2 dopamine receptors activates the Gi signalling cascade which leads to increased cAMP. Pergolide is an agonist at D1 - D5 receptors Presynaptic Neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Dopamine is produced in the Ventral Tegmental Area of the brain Nigrostriatal pathway Synapse Blood vessel - Blood Brain Barrier Brain passive diffusion Pergolide is taken orally and absorbed via the gastrointestinal tract