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D(2) dopamine
receptor
D(3) dopamine
receptor
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Sodium-
dependent
dopamine
transporter
Synaptic
vesicular amine
transporter
Aromatic-L-
amino-acid
decarboxylase
Tyrosine
3-monooxygenase
Dopamine
Ca
+
Rotigotine
Ca
+
Dopamine
Dopamine
Rotigotine
Rotigotine
L-Dopa
CO
2
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
Na
+
Na
+
Pyridoxal
5'-phosphate
Gi Signaling
Cascade
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Rotigotine has highest
affinity for D3 receptor and
increases dopamine activity
in the brain
Neuronal excitability
Rotigotine has a high
affinity for D2, D3
receptors and moderate
affinity for D4 receptors
Brain
Nigrostriatal pathway
Rotigotine is functional in
the mesolimbic and
tuberoinfundibular pathways
Blood vessel - blood brain
barrier
Passive Diffusion
Caudate-Putamen
Rotigotine is administered
as a transdermal patch
DRD2
DRD3
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
Dopamine
Calcium
Rotigotine
Calcium
Dopamine
Dopamine
Rotigotine
Rotigotine
L-Dopa
Carbon dioxide
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
Sodium
Sodium
Gi Signaling
Cascade
DRD2
DRD3
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
LDP
Ca
+
Rotigot
Ca
+
LDP
LDP
Rotigot
Rotigot
L-Dopa
CO
2
Tyr
BH4
O
2
BH3
H
2
O
Na
+
Na
+
Pyr-5'P
Gi Si C
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Rotigotine has highest
affinity for D3 receptor and
increases dopamine activity
in the brain
Neuronal excitability
Rotigotine has a high
affinity for D2, D3
receptors and moderate
affinity for D4 receptors
Brain
Nigrostriatal pathway
Rotigotine is functional in
the mesolimbic and
tuberoinfundibular pathways
Blood vessel - blood brain
barrier
Passive Diffusion
Caudate-Putamen
Rotigotine is administered
as a transdermal patch