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D(2) dopamine receptor D(3) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Rotigotine Ca+ Dopamine Dopamine Rotigotine Rotigotine L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi Signaling Cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Rotigotine has highest affinity for D3 receptor and increases dopamine activity in the brain Neuronal excitability Rotigotine has a high affinity for D2, D3 receptors and moderate affinity for D4 receptors Brain Nigrostriatal pathway Rotigotine is functional in the mesolimbic and tuberoinfundibular pathways Blood vessel - blood brain barrier Passive Diffusion Caudate-Putamen Rotigotine is administered as a transdermal patch
DRD2 DRD3 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH Dopamine Calcium Rotigotine Calcium Dopamine Dopamine Rotigotine Rotigotine L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi Signaling Cascade
DRD2 DRD3 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Rotigot Ca+ LDP LDP Rotigot Rotigot L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi Si C Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Rotigotine has highest affinity for D3 receptor and increases dopamine activity in the brain Neuronal excitability Rotigotine has a high affinity for D2, D3 receptors and moderate affinity for D4 receptors Brain Nigrostriatal pathway Rotigotine is functional in the mesolimbic and tuberoinfundibular pathways Blood vessel - blood brain barrier Passive Diffusion Caudate-Putamen Rotigotine is administered as a transdermal patch