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Pathway Description
nAchR Smooth Muscle Contraction
Homo sapiens
Physiological Pathway
Created: 2023-08-09
Last Updated: 2023-11-27
Acetylcholine released from neuromuscular neurons activates nicotinic acetylcholine receptors (nAchR) on smooth muscle membranes. This causes the receptor to open, causing sodium to flow into the smooth muscle myocyte. This high concentration of sodium activates the L-type voltage gated calcium channel. Calcium enters the smooth muscle myocyte and binds to calmodulin. Calcium bound calmodulin activates myosin kinase which phosphorylates myosin light chain, leading to interaction between actin and myosin, producing muscle contraction.
References
nAchR Smooth Muscle Contraction References
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Pubmed: 2789520
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Pubmed: 10049321
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Pubmed: 1385409
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Pubmed: 7916667
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Pubmed: 9880589
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Pubmed: 10766861
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Pubmed: 10762351
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