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Myosin light chain kinase, smooth muscle Adenylate cyclase type 9 cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit Protein kinase C alpha type Beta-2 adrenergic receptor Myosin LC-P Myosin light chain 3 Inositol 1,4,5- trisphosphate receptor type 1 Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent L-type calcium channel subunit alpha-1C Myosin light chain phosphatase Intermediate conductance calcium- activated potassium channel protein 4 Phospholipase C G protein complex Guanine nucleotide- binding protein alpha Calmodulin-1 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Voltage- dependent calcium channel subunit alpha-2/delta-1 Nadolol Ca+ Ca+ K+ K+ Ca+ Nadolol GDP GTP ATP cAMP Inositol 1,4,5-trisphosphate Phosphatidylinositol 4,5-bisphosphate Diacylglycerol GTP Pi Pi Pi Calcium Ca+ Muscle Contraction Muscle Relaxation Magnesium Calcium Manganese Sarcoplasmic Reticulum Cytosol Vascular Smooth Muscle Cell Nadolol binds to beta-2 adrenergic receptor. The G protein signalling cascade is blocked from occurring as the beta receptor is inhibited Reduced cAMP means PKA isn't activated, allowing for intracellular levels of potassium and calcium to increase Adenylyl cyclase is unable to be activated leading to decreased intracellular cAMP There is an overall increase in calcium levels in the cytosol. Calcium readily binds to calmodulin High concentrations of myosin LC-P allow for muscle contraction Constriction Myosin unbinds from actin causing the sarcomere filaments to slide leading to muscle relaxation. Actin Filament Myosin Filament Nadolol is administered as an oral tablet
MYLK ADCY9 PRKAR1A PRKAR2A PRKCA ADRB2 MYL3 MYL3 ITPR1 CACNB1 CACNA1C PPP1CB KCNN4 PLCB1 GNB1 GNAS CALM1 GNB1 GNG12 CACNA2D1 Nadolol Calcium Calcium Potassium Potassium Calcium Nadolol Guanosine diphosphate Guanosine triphosphate Adenosine triphosphate cAMP Inositol 1,4,5- trisphosphate Phosphatidylinositol 4,5- bisphosphate Diacylglycerol Guanosine triphosphate Phosphate Phosphate Phosphate Calcium Muscle Contraction Muscle Relaxation