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D(2) dopamine
receptor
D(3) dopamine
receptor
D(2) dopamine
receptor
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Sodium-
dependent
dopamine
transporter
Vesicle-
associated
membrane
protein 2
Synaptic
vesicular amine
transporter
Aromatic-L-
amino-acid
decarboxylase
Tyrosine
3-monooxygenase
Dopamine
Ca
+
Lisuride
Lisuride
Ca
+
Dopamine
Lisuride
Lisuride
Dopamine
L-Dopa
CO
2
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
Na
+
Na
+
Pyridoxal
5'-phosphate
Gi Signaling
Cascade
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Lisuride increases dopamine
activity in the brain
Neuronal excitability
Lisuride has affinity for
D2, D3 receptors and
moderate affinity for D4
receptors
Brain
Nigrostriatal pathway
Blood vessel - blood brain
barrier
Passive Diffusion
Caudate-Putamen
Lisuride is administered
orally and absorbed from the
gastrointestinal tract
DRD2
DRD3
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
VAMP2
SLC18A2
DDC
TH
Dopamine
Calcium
Lisuride
Lisuride
Calcium
Dopamine
Lisuride
Lisuride
Dopamine
L-Dopa
Carbon dioxide
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
Sodium
Sodium
Gi Signaling
Cascade
DRD2
DRD3
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
VAMP2
SLC18A2
DDC
TH
LDP
Ca
+
Lisurid
Lisurid
Ca
+
LDP
Lisurid
Lisurid
LDP
L-Dopa
CO
2
Tyr
BH4
O
2
BH3
H
2
O
Na
+
Na
+
Pyr-5'P
Gi Si C
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Lisuride increases dopamine
activity in the brain
Neuronal excitability
Lisuride has affinity for
D2, D3 receptors and
moderate affinity for D4
receptors
Brain
Nigrostriatal pathway
Blood vessel - blood brain
barrier
Passive Diffusion
Caudate-Putamen
Lisuride is administered
orally and absorbed from the
gastrointestinal tract