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cAMP-dependent
protein kinase
type II-beta
regulatory
subunit
cAMP-dependent
protein kinase
catalytic
subunit alpha
cAMP-dependent
protein kinase
catalytic
subunit beta
cAMP-dependent
protein kinase
type I-alpha
regulatory
subunit
cAMP-dependent
protein kinase
catalytic
subunit gamma
cAMP-dependent
protein kinase
type I-beta
regulatory
subunit
cAMP-dependent
protein kinase
type II-alpha
regulatory
subunit
D(2) dopamine
receptor
Adenylate
cyclase type 2
Guanine
nucleotide-
binding protein
G(s) subunit
alpha isoforms
short
Guanine
nucleotide-
binding protein
G(i) subunit
alpha-1
Synaptic
vesicular amine
transporter
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Voltage-
dependent
N-type calcium
channel subunit
alpha-1B
Sodium-
dependent
dopamine
transporter
Tyrosine
3-monooxygenase
Aromatic-L-
amino-acid
decarboxylase
cAMP
Ca
+
Dopamine
Dopamine
Ergoloid mesylate
Dopamine
Ca
+
Ergoloid mesylate
Ergoloid mesylate
L-Tyrosine
L-Dopa
CO
2
ATP
PP
i
Na
+
Na
+
Fe2+
Pyridoxal
5'-phosphate
Neuronal
Excitability
Magnesium
Activation of D2 dopamine
receptors activates the Gi
signalling cascade which
leads to increased cAMP.
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Postsynaptic Neuron
Cytosol
Dopamine is produced in the
Ventral Tegmental Area of
the brain
Nigrostriatal pathway
Synapse
Blood vessel - Blood Brain
Barrier
Brain
Ergoloid mesylate is taken
orally and absorbed from the
gastrointestinal tract
passive diffusion
Ergoloid mesylate increases
both the blood flow and
cerebral metabolism.
PRKAR2B
PRKACA
PRKACB
PRKAR1A
PRKACG
PRKAR1B
PRKAR2A
DRD2
ADCY2
GNAS
GNAI1
SLC18A2
CACNA2D1
CACNA2D2
CACNA1B
SLC6A3
TH
DDC
cAMP
Calcium
Dopamine
Dopamine
Ergoloid
mesylate
Dopamine
Calcium
Ergoloid
mesylate
Ergoloid
mesylate
L-Tyrosine
L-Dopa
Carbon dioxide
Adenosine
triphosphate
Pyrophosphate
Sodium
Sodium
Neuronal
Excitability
PRKAR2B
PRKACA
PRKACB
PRKAR1A
PRKACG
PRKAR1B
PRKAR2A
DRD2
ADCY2
GNAS
GNAI1
SLC18A2
CACNA2D1
CACNA2D2
CACNA1B
SLC6A3
TH
DDC
cAMP
Ca
+
LDP
LDP
EM
LDP
Ca
+
EM
EM
Tyr
L-Dopa
CO
2
ATP
PP
i
Na
+
Na
+
Fe2+
Pyr-5'P
Neu Exc
Mg2+
Activation of D2 dopamine
receptors activates the Gi
signalling cascade which
leads to increased cAMP.