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D(2) dopamine receptor D(3) dopamine receptor D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Vesicle- associated membrane protein 2 Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Lisuride Cariprazine Ca+ Dopamine Cariprazine Cariprazine Dopamine L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi Signaling Cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Cariprazine increases dopamine activity in the brain ↓ Positive, negative and cognitive symptoms of schizophrenia Cariprazine is a partial agonist of D2, D3 receptors. Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Cariprazine has a high affinity for D3 receptors Cariprazine is administered orally and absorbed from the gastrointestinal tract
DRD2 DRD3 DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 VAMP2 DDC TH Dopamine Calcium Lisuride Cariprazine Calcium Dopamine Cariprazine Cariprazine Dopamine L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi Signaling Cascade
DRD2 DRD3 DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 VAMP2 DDC TH LDP Ca+ Lisurid Carip Ca+ LDP Carip Carip LDP L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi Si C Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Cariprazine increases dopamine activity in the brain ↓ Positive, negative and cognitive symptoms of schizophrenia Cariprazine is a partial agonist of D2, D3 receptors. Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Cariprazine has a high affinity for D3 receptors Cariprazine is administered orally and absorbed from the gastrointestinal tract
DRD2 DRD3 DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 VAMP2 DDC TH LDP Ca2+ Lisurid Carip Ca2+ LDP Carip Carip LDP L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Gi Si C