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Pathway Description
Cabergoline Mechanism of Action Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-08-14
Last Updated: 2023-11-27
Cabergoline stimulates centrally-located dopaminergic D2- and D3-receptors. Cabergoline is a long-acting agonist with a high affinity for D2 receptors. It also exhibits: weak agonist activity (in order of decreasing binding affinities) on 5-hydroxytryptamine (5-HT)2B, 5-HT2A, 5-HT1D, dopamine D4, 5-HT1A, dopamine D1, 5-HT1B and 5-HT2C receptors and antagonist activity on α2B, α2A, and α2C receptors. Cabergoline is probably more effective and causes fewer adverse effects than bromocriptine. However, it is much more expensive. Cabergoline is often used in patients who cannot tolerate the adverse effects of bromocriptine or in those who do not respond to bromocriptine. Cabergoline stops the brain from making and releasing the prolactin hormone from the anterior pituitary gland. The hypothalamic control of prolactin secretion is mostly inhibitory by prolactin inhibiting factor and dopamine is the main inhibitor that acts via type 2 dopamine (D2) receptor located on lactotrophs. Cabergoline is used in the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). It may also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease..
References
Cabergoline Mechanism of Action Pathway References
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