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D(2) dopamine
receptor
Synaptic
vesicular amine
transporter
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Voltage-
dependent
N-type calcium
channel subunit
alpha-1B
Sodium-
dependent
dopamine
transporter
Tyrosine
3-monooxygenase
Aromatic-L-
amino-acid
decarboxylase
Ca
+
Dopamine
Dopamine
Cabergoline
cAMP
Dopamine
Ca
+
Cabergoline
Cabergoline
L-Tyrosine
L-Dopa
CO
2
Na
+
Na
+
Fe2+
Pyridoxal
5'-phosphate
Prolactin
synthesis and
release
short loop negative feed
back from hypothalamus to
the production of dopamine
by prolactin
Carbegoline is a D2 receptor
agonist.
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Postsynaptic Neuron
Cytosol
Dopamine is produced in the
Ventral Tegmental Area of
the brain
Dopamine receptors on the
lactotrophs in the
hypothalamus
Synapse
Blood vessel - Blood Brain
Barrier
Brain
Passive diffusion
Cabergoline is taken orally
and absorbed from the
gastrointestinal tract
Tuberoinfundibular pathway
Prolactin release-inhibiting
hormone (PRIH) is the
catecholamine
neurotransmitter dopamine
Controlled prolactin release
Prolactin-inhibiting factor
(PIF)- dopamine, controls
the secretion of prolactin
from the hypothalamus
Sulking, stress,use of some
medications increase the
secretion of prolactin
DRD2
SLC18A2
CACNA2D1
CACNA2D2
CACNA1B
SLC6A3
TH
DDC
Calcium
Dopamine
Dopamine
Cabergoline
cAMP
Dopamine
Calcium
Cabergoline
Cabergoline
L-Tyrosine
L-Dopa
Carbon dioxide
Sodium
Sodium
Prolactin
synthesis and
release
DRD2
SLC18A2
CACNA2D1
CACNA2D2
CACNA1B
SLC6A3
TH
DDC
Ca
+
LDP
LDP
Cabergo
cAMP
LDP
Ca
+
Cabergo
Cabergo
Tyr
L-Dopa
CO
2
Na
+
Na
+
Fe2+
Pyr-5'P
P s a r
short loop negative feed
back from hypothalamus to
the production of dopamine
by prolactin
Carbegoline is a D2 receptor
agonist.
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Postsynaptic Neuron
Cytosol
Dopamine is produced in the
Ventral Tegmental Area of
the brain
Dopamine receptors on the
lactotrophs in the
hypothalamus
Synapse
Blood vessel - Blood Brain
Barrier
Brain
Passive diffusion
Cabergoline is taken orally
and absorbed from the
gastrointestinal tract
Tuberoinfundibular pathway
Prolactin release-inhibiting
hormone (PRIH) is the
catecholamine
neurotransmitter dopamine
Controlled prolactin release
Prolactin-inhibiting factor
(PIF)- dopamine, controls
the secretion of prolactin
from the hypothalamus
Sulking, stress,use of some
medications increase the
secretion of prolactin
DRD2
SLC18A2
CACNA2D1
CACNA2D2
CACNA1B
SLC6A3
TH
DDC
Ca2+
LDP
LDP
Cabergo
cAMP
LDP
Ca2+
Cabergo
Cabergo
Tyr
L-Dopa
CO2
Na+
Na+
P s a r