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Gamma-
aminobutyric
acid type B
receptor
Voltage-
dependent
T-type calcium
channel subunit
alpha-1H
Voltage-
dependent
T-type calcium
channel subunit
alpha-1G
Adenylate
cyclase type 1
Vesicular
inhibitory
amino acid
transporter
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Glutamate
decarboxylase 1
γ-Aminobutyric acid
cAMP
γ-Aminobutyric acid
Ca
+
Paramethadione
L-Glutamic acid
γ-Aminobutyric acid
Ca
+
Ca
+
Ca
+
Paramethadione
Paramethadione
CO
2
ATP
PP
i
Magnesium
Pyridoxal
5'-phosphate
Gi/o signalling
Glutamate
Metabolism
Hyperpolarization
Hyperpolarization leading to
reduced depolarization and
excitability
Presynaptic Neuron
Post Synaptic Neuron
Synaptic Vesicle
Cytosol
Cytosol
Synapse
Paramethadione binds to
T-type calcium channels and
inhibits calcium influx.
Hyperpolarization prevents
absence seizures
GABA release linked with
petit mal seizures
Paramethadione is
administered as an oral
tablet
GABBR2
CACNA1H
CACNA1G
ADCY1
SLC32A1
CACNA1A
GAD1
γ-Aminobutyric
acid
cAMP
γ-Aminobutyric
acid
Calcium
Paramethadione
L-Glutamic acid
γ-Aminobutyric
acid
Calcium
Calcium
Calcium
Paramethadione
Paramethadione
Carbon dioxide
Adenosine
triphosphate
Pyrophosphate
Gi/o signalling
Glutamate
Metabolism
Hyperpolarization
GABBR2
CACNA1H
CACNA1G
ADCY1
SLC32A1
CACNA1A
GAD1
GABA
cAMP
GABA
Ca
+
Paradio
Glu
GABA
Ca
+
Ca
+
Ca
+
Paradio
Paradio
CO
2
ATP
PP
i
Mg2+
Pyr-5'P
Gi/ sig
PW000003
Hyper
Hyperpolarization leading to
reduced depolarization and
excitability
Presynaptic Neuron
Post Synaptic Neuron
Synaptic Vesicle
Cytosol
Cytosol
Synapse
Paramethadione binds to
T-type calcium channels and
inhibits calcium influx.
Hyperpolarization prevents
absence seizures
GABA release linked with
petit mal seizures
Paramethadione is
administered as an oral
tablet