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Adenylate cyclase type 10 Myosin light chain kinase, smooth muscle PKA complex PKA complex Protein kinase C Muscarinic acetylcholine receptor M2 Myosin LC-P Myosin light chain 3 Inositol 1,4,5- trisphosphate receptor type 1 Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent L-type calcium channel subunit alpha-1C Myosin light chain phosphatase Calmodulin Intermediate conductance calcium- activated potassium channel protein 4 Phospholipase C ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Calmodulin Voltage- dependent calcium channel subunit alpha-2/delta-1 Pilocarpine Ca+ Ca+ K+ K+ Ca+ K+ K+ ATP cAMP Inositol 1,4,5-trisphosphate Phosphatidylinositol 4,5-bisphosphate Diacylglycerol Pi Pi Pi Pi Calcium Ca+ Muscle Contraction Muscle Relaxation G Protien Signalling Cascade Magnesium Calcium Manganese Sarcoplasmic Reticulum Cytosol Ciliary Muscle Cell Activated PKA can phosphorylate calcium activated potassium channels causing potassium efflux and promoting hyperpolarization. Activated PKA phosphorylates the IP3 receptor to reduce its affinity for IP3. Activated PKA phosphorylates phospholipase C. There is an overall decrease in calcium levels in the cytosol. Decreased calcium is unable to bind readily to calmodulin. The inhibition of myosin light chain kinase prevents the synthesis of Myosin LC-P which leads to a high concentration of myosin light chain and muscle relaxation. Myosin binds actin causing the sarcomere filaments to slide resulting in muscle contraction. Activates ATP-sensitive potassium channels via cAMP mediated phosphorylation. Actin Filament Myosin Filament Since the receptor isn't activated, adenylyl cyclase is no longer inhibited allowing for cAMP production M2 receptors activate Gi protein signalling which inhibits adenylyl cyclase Pilocarpine is a M2 muscarinic receptor agonist Pilocarpine is administered as an eye drop